Peptides

Caspase 3 (Apopain) Substrate 1m, fluorogenic - 5 mg

142,00
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  • Cat.Number : AS-25262-5
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    In stock

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Caspase-3 substrate with Km = 9.7 µM; Caspase-7 substrate with Km = 11 µM;
AMC (7-amino-4-methylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities. Cleavage of AMC peptides by caspases generates strongly fluorescent AMC that is monitored fluorimetrically at 440-460 nm with excitation of 340-350 nm.

Specifications

Chemistry
Sequence one letter code
  • Ac-DEVD-AMC
Sequence three letter code
  • Ac-Asp-Glu-Val-Asp-AMC
CAS registry number
  • 169332-61-0
Molecular Formula
  • C30H37N5O13
Molecular Mass/ Weight
  • 675.5
Properties
Absorbance (nm)
  • 350
Emission (nm)
  • 440
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing.

FEBS Lett . 2006 Jun 09 ; 580(15 3739 | DOI : 10.1016/j.febslet.2006.05.066

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Curcumin ameliorates ethanol and nonethanol experimental pancreatitis.

Am J Physiol Gastrointest Liver Physiol. . 2003 Jan 01 ; 284(1) G85 | DOI : 10.1152/ajpgi.00138.2002

  • I. Gukovsky
  • et al

Induction of apoptosis by rosemary polyphenols in HL-60 cells.

Orient Foods Herbs chapter . 2003 Aug 05 ; 8 121 | DOI : 10.1021/bk-2003-0859.ch008.

  • S.Y. Lin-Shiau
  • et al

Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells: Roles in cell injury processes of pancreatitis.

J Biol Chem . 2002 Apr 18 ; 277(25) 22393 | DOI : 10.1074/jbc.M202929200

  • A.S. Gukovskaya
  • et al

Trophoblast differentiation modulates the activity of caspases in primary cultures of term human trophoblasts.

Ped Res . 2002 Sep 01 ; 52(3) 411 | DOI : 10.1203/00006450-200209000-00018

  • K. Yusef
  • et al