Endothelin 1, human, HiLyte™ Fluor 488-labeled - 0.25 mg
- Cat.Number : AS-64817-025
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This is a fluorescent (HiLyte™ Fluor 488)-labeled Endothelin 1 (ET-1) peptide, Abs/Em=503/528 nm. ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.
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Citations
Desensitization and internalization of endothelin receptor A: impact of G protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation.
J Biol Chem . 2013 Sep 24 ; 288(45) 32138 | DOI : 10.1074/jbc.M113.461566.
- F. Gärtner
- et al