Peptides

Fibrinopeptide A, human - 1 mg

61.00
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  • Cat.Number : AS-20735
  • Availability :
    In stock

Quantity

Fibrinopeptides A and B (FPA and FPB) are short amino acid sequences located at the N-terminus of fibrinogen A and B, respectively. Fibrinopeptide A is a 16-amino acid cleavage product induced by thrombin. Together with Fibrinopeptide B, it uncovers the E domain of fibrinogen. The residual protein, fibrin monomer, polymerizes to form fibrin clot. Thus, liberation of approximately 4 ng/ml of FPA per milligram of fibrinogen is closely linked to clot formation. Because proteolysis of fibrinogen accelerates early after the onset of thrombosis, marked elevations in FPA levels are expected early after the onset of clotting. Elevation of Fibrinopeptide A levels in plasma is seen in association with disorders such as disseminated intravascular coagulation, deep venous thrombosis, arterial thrombosis, and malignancy. Given the short half-life of FPA in plasma (3-5 min) and the conversion of fibrinogen to fibrin is particularly rapid and early during the course of thrombosis, measuring for elevated FPA levels in samples obtained very early after the onset of symptoms of transmural infarction would be beneficial to assess association with acute coronary thrombosis. Elevated FPA levels appear to be a marker during the course of coronary thrombosis .

Specifications

Chemistry
Sequence one letter code
  • ADSGEGDFLAEGGGVR
Sequence three letter code
  • H-Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg-OH
CAS registry number
  • 25422-31-5
Molecular Formula
  • C63H97N19O26
Molecular Mass/ Weight
  • 1536.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Fragmentation of Singly Protonated Peptides via Interaction with Metastable Rare Gas Atoms.

Anal Chem . 2009 Jan 15 ; 81(2) 725 | DOI : 10.1021/ac802214e

  • V. Berkout
  • et al