Protein
HIV-1 protease, recombinant - 5 µg
€432.00
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- Cat.Number : AS-72028-5
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The 10~12 kDa aspartic protease of human immunodeficiency virus-1 (HIV-1), active only when it forms a homodimer, is required for the post-translational cleavage of the precursor polyproteins, Gag, Gag-Pol, Pol, and Nef. Since the cleavages of precursors are essential for the maturation of HIV infectious particles, this protease is one of the key targets for developing anti-AIDS drugs
The recombinant HIV-1 protease (wild type, NCBI accession: NC_001802) contains the 99 amino acid sequence as reported by Schneider, et al. (Cell 54, 363;1988) with 6x His-tag at its C-terminal. HIV-1 protease activity can be measured using enzymatic assay with FRET substrates.
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