Protein

Human recombinant a-Synuclein (1-140), biotin labeled - 200 µg

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  • Cat.Number : AS-55581
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    In stock
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Parkinson's disease is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of α-synuclein is a critical step in the etiology of Parkinson's disease (PD). α-Synuclein is an abundant brain protein of 140 residues that is present in high concentration at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested for α-synuclein, and it also appears to be involved in vesicle release and trafficking. In vitro incubation in the presence of a specific amount of salt (i.e. 0.1M NaCl) with agitation shows α-synuclein forming fibrilous structure.

Recombinant human α-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with biotin.

Specifications

Chemistry
UniProt number
  • P37840
Molecular Mass/ Weight
  • 14.5 kDa
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Purification Method
  • Purified
Purity
  • >90%
Storage & stability
Form
  • In solution
Storage Buffer
  • 10 mM sodium phosphate buffer (pH=7.4)
Storage Conditions
  • Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for up to 12 months. Keep in dark and avoid repeated freeze-thaw cycles.
Activity
Application
Biomarker Target
Specificity
  • human a-synuclein (1-140)
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human
Codes
Code Nacres
  • NA.27

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