Protein

Human recombinant a-Synuclein (1-140), HiLyte™ Fluor 488 labeled - 200 µg

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  • Cat.Number : AS-55457
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    In stock
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Parkinson's disease (PD) is predominantly a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra. The cause of the disease is unknown, but substantial evidence suggests that the aggregation of α-synuclein is a critical step in the etiology of PD. α-Synuclein is an abundant brain protein of 140 residues that is present in high concentration at presynaptic terminals and is found in both soluble and membrane-associated fractions of the brain. Several possible functions have been suggested, among which are vesicle release and trafficking. In vitro incubation in the presence of salt (i.e. 0.1M NaCl) with agitation causes α-synuclein to form fibrils.

The recombinant human α-synuclein (1-140) (GenBank Accession # NP_000336) was expressed and purified from E. coli and conjugated with the fluorescence dye HiLyte™ Fluor 488. Green fluorescence: Excitation/Emission wavelengths= 503 nm/525 nm

Specifications

Chemistry
UniProt number
  • P37840
Molecular Mass/ Weight
  • 14.5 kDa
Properties
Absorbance (nm)
  • 503
Emission (nm)
  • 525
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Purification Method
  • Purified
Purity
  • >90%
Storage & stability
Form
  • In solution
Storage Buffer
  • 10 mM sodium phosphate buffer (pH=7.0)
Storage Conditions
  • Store at 2-4 ºC for immediate use within 1 week or at –80 ºC for up to 12 months. Keep in dark and avoid repeated freeze-thaw cycles
Activity
Application
Biomarker Target
Detection Method
Specificity
  • human a-synuclein (1-140)
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human
Codes
Code Nacres
  • NA.27

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