MMP-12 (Catalytic Domain), human recombinant
- Cat.Number : AS-55525-1
- Manufacturer Ref. :
-
Availability :
In stock
- Shipping conditions : Ice delivery fees must be applied
Alternative choices
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is involved in smoke-induced emphysema, tumor and other diseases. MMP-12 is secreted as a 54-kDa zymogen and becomes the mature 45-kDa active form after proteolytic cleavage. MMP-12 has a broad range of substrates, including α-1 proteinase inhibitor, α-2 antiplasmin, plasminogen activator inhibitor-2, collagen IV, laminin, fibronectin, elastin, but not interstitial collagens.
The sequence (Accession # NP_002417) corresponding to the catalytic domain (aa 106-267) of Human MMP-12 was expressed in E. coli. The recombinant human MMP-12 was purified from bacterial lysate and refolded using proprietary technique. The molecular weight of the recombinant Human MMP-12 Catalytic Domain is 18 kDa.
Specifications
Chemistry | |
UniProt number |
|
---|---|
Molecular Mass/ Weight |
|
Modification | |
Conjugation |
|
Quantity & Purity | |
Concentration |
|
Purification Method |
|
Purity |
|
Storage & stability | |
Form |
|
Storage Buffer |
|
Storage Conditions |
|
Activity | |
Application | |
Biomarker Target | |
Specificity |
|
Research Area | |
Sub-category Research Area | |
Usage |
|
Source | |
Host | |
Source / Species |
|
Codes | |
Code Nacres |
|
Downloads
You may also be interested in the following product(s)
![Tube of ADAMTS-4 FRET substrate peptide](/assets/cache/a0aa296b-5044-4782-9c0b-ca0641aff141/500x500/as-60431-1-img-en-as-60431-1-01.jpg)
![Image of a kit SensoLyte 490 MMP-12 Assay Kit Fluorimetric](/assets/cache/863486c2-21d1-4680-93fd-7e315e459c6c/500x500/as-71137-img-en-as-71137-01.jpg)
![Image of a kit SensoLyte 520 MMP-12 Assay Kit Fluorimetric](/assets/cache/cee78ca4-a87d-499e-b079-04054be1944f/500x500/as-71157-img-en-as-71157-01.jpg)