Protein

MMP-12 (Catalytic Domain), human recombinant

91,00
Check your price
  • Cat.Number : AS-55525-1
  • Availability :
    In stock
  • Shipping conditions : Ice delivery fees must be applied

Select specification

Size

Quantity

Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is involved in smoke-induced emphysema, tumor and other diseases. MMP-12 is secreted as a 54-kDa zymogen and becomes the mature 45-kDa active form after proteolytic cleavage. MMP-12 has a broad range of substrates, including α-1 proteinase inhibitor, α-2 antiplasmin, plasminogen activator inhibitor-2, collagen IV, laminin, fibronectin, elastin, but not interstitial collagens.

The sequence (Accession # NP_002417) corresponding to the catalytic domain (aa 106-267) of Human MMP-12 was expressed in E. coli. The recombinant human MMP-12 was purified from bacterial lysate and refolded using proprietary technique. The molecular weight of the recombinant Human MMP-12 Catalytic Domain is 18 kDa.

Specifications

Chemistry
UniProt number
  • P39900 (pro-MMP-12)
Molecular Mass/ Weight
  • 18 kDa
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • lot dependent
Purification Method
  • Purified
Purity
  • >95%
Storage & stability
Form
  • In solution
Storage Buffer
  • 150 mM NaCl, 20 mM Tris-HCl, 10 mM CaCl2, 1 µM ZnCl2, pH=7.5
Storage Conditions
  • Store at -80 ºC. Avoid repeated freeze-thaw cycles.
Activity
Application
Biomarker Target
Specificity
  • Catalytic domain (aa 106-267) of Human MMP-12
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human
Codes
Code Nacres
  • NA.27

You may also be interested in the following product(s)

Tube of ADAMTS-4 FRET substrate peptide

ADAMTS-4/Aggrecanase FRET Substrate, WAAG-3R - 1 mg

Cat.Number : AS-60431-1
229,00