Peptides

Renin FRET Substrate (5-FAM/QXL™520) - 0.1 mg

209,00
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  • Cat.Number : AS-61872-01
  • Availability :
    In stock

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Quantity

This FRET peptide is a specific substrate for renin. Aspartyl protease cleaves angiotensinogen to yield angiotensin I, which is further converted to angiotensin II. The renin-angiotensin system is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function. It governs body fluid and electrolyte balance, as well as arterial pressure. Since an overactive renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. This renin peptide substrate may be used for screening of renin inhibitors. In the FRET peptide, the fluorescence of 5-FAM is quenched by QXL® 520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm. This substrate is employed in the SensoLyte® 520 Renin Assay Kit, cat # 72040.

Specifications

Chemistry
Molecular Mass/ Weight
  • 2000 - 2200
Properties
Absorbance (nm)
  • 490
Emission (nm)
  • 520
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Codes
Code Nacres
  • NA.26

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