C3a mediates a variety of proinflammatory
and immunoregulatory functions
The C3a anaphylatoxin is a 78-amino-acid peptide derived from the proteolytic cleavage of the complement protein C3. It mediates a variety of proinflammatory and immunoregulatory functions through its binding to the seven-transmembrane segment G-protein-coupled C3a receptor (C3aR).
- C3a induces smooth muscle contraction, increases vascular permeability, arachidonic acid metabolism, cytokine release, cellular degranulation and chemotaxis.
- C3a is involved in microbial host defense, immune regulation and protection against toxic insult.
- C3a enhances granulocyte adhesion to endothelial and epithelial cell monolayers.
- Anaphylatoxin C3a inhibits the generation of leukocyte inhibitory factor activity by human mononuclear leukocytes and T lymphocytes cultured with the mitogens in-vitro.
- Reca, R. et al. Blood 101, 3784 (2003)
- Gao, J. et al. J. Biol. Chem. 278, 37902 (2003)
- Kalant, D. et al. J. Biol. Chem 278, 11123 (2003)
- Payan, DG. et al. J. Exp. Med. 156, 756 (1982)
- Daffern, PJ. et al. J. Exp. Med. 181, 2119 (1995)
- Takabayashi, T. et al. J. Immunol. 156, 3455 (1996)
- Hartmann, K. et al. Blood. 89, 2863 (1997)
- Jagels, M. et al. Immunopharmacol. 46, 209 (2000)