VHH ANTIBODY CDMO
GMP VHH Antibody
Manufacturing Platform
We’ve developed a microbial platform for GMP-grade VHH antibody production also referred to as nanobodies®. Optimized for E. coli and P. pastoris (K. phaffii), our platform enables fast, high-quality delivery of custom single-domain antibodies in monomer or multimer formats, from research cell bank to GMP batch in just 8 months.
VHH production toolbox
built on diverse models
We’ve developed a robust VHH production toolbox in E. coli and P. pastoris, tested on a broad range of antibody formats including
mono, bi, and tri specific formats, with isoelectric points from pI 5 to 9 and varied hydrophobicity profiles. This platform integrates
various host systems, fermentation strategies, purification, and QC methods to rapidly fine-tune each production process
and deliver GMP single domain antibodies adapted to your needs.
Fast track your GMP VHH project
Starting from your research cell bank, we rapidly define the most suitable fermentation and purification process for your VHH antibody.
Our microbial expression platform and CDMO services support GMP-grade VHH production for preclinical studies, clinical trials, and commercial supply.
With scalable production and GMP compliant operations, we accelerate your VHH-based molecule to market and offer the option to
validate your process for long-term commercial success.
GMP QC Package
Our GMP QC package includes a full panel of analytical methods for GMP-grade VHH release.
Optional tests can be added based on your molecule’s specific needs.
| Attributes | Testing |
| Identity | SDS PAGE Western Blotting SE-HPLC |
| Purity | Molecular size distribution by SE-HPLC |
| Appearance | Colorimetry Turbidimetry |
| Physico-chemical | pH |
| Protein content | UV / µBCA / Lowry |
| Impurity | Host Cell Protein by ELISA Host Cell DNA by qPCR |
| Safety | Endotoxin Bioburden |
| Residual | Methanol / IPTG Protein A (ELISA) |
Optional QCs
| Attributes | Testing |
| Identity | ESI-Q-TOF RP-HPLC |
| Purity | RP-HPLC |
| Physico-chemical | Visible particles Osmolarity |
| Potency | Antigen binding assay by SPR ELISA |
High quality single-domain antibodies
Full Service CDMO
From scale-up to commercial supply, we support your project every step of the way.
Large scale manufacturing options
We offer scalable microbial production to support later-stage clinical trials and commercial supply.
PPQ and Commercial Experience
Since 1994 our team has acquired extensive experience managing PPQ campaigns and supply for commercial use.
Helping you navigate late phase manufacturing
With our flexible approach, we act as a long-term partner committed to your success
Explore our related services
From RUO-grade VHH antibodies to GMP antibody fragments, recombinant proteins, and conjugates, we provide a broad range of CDMO services to support your therapeutic programs. Our solutions help you advance from early discovery to clinical and commercial manufacturing with confidence.
