Protein

EndoClear™ human recombinant a-Synuclein protein

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  • Cat.Number : AS-55555-100
  • Availability :
    In stock
  • Shipping conditions : Ice delivery fees must be applied

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α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.

*For more stringent applications, EndoClear™Plus offers the lowest endotoxin research grade
alpha-synuclein protein available in the market.

The sequence (Accession # NP_000336) corresponding to the full length human α-synuclein protein without affinity tag was expressed in E. coli. The recombinant α-synuclein protein was purified from bacterial lysate using proprietary method. The molecular mass of the recombinant α-synuclein protein is 14.5 kDa.

Specifications

Chemistry
UniProt number
  • P37840
Molecular Mass/ Weight
  • 14.5 kDa
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • none (lyophilized)
Purification Method
  • Purified
Purity
  • >95%
Endotoxin content
  • < 0.1EU/ug protein
Storage & stability
Form
  • Lyophilized
Storage Buffer
  • The purified a-synuclein is supplied as lyophilized powder nearly salt free.
Storage Conditions
  • Store at 2-4 ºC for immediate use within 1-2 weeks or at –80 ºC for up to 12 months.
Activity
Application
Biomarker Target
Specificity
  • human a-synuclein (1-140)
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • human
Codes
Code Nacres
  • NA.27

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