α-Synuclein is a major component of Lewy bodies in the affected neurons in Parkinson's disease. This protein has a mass of 14.5 kDa (140 amino acids long) and consists of a conserved degenerative amino-terminal domain and an acidic carboxyl-terminal with higher sequence divergence. α-Synuclein is predominantly expressed in brain, specifically in cerebellum, thalamus, neocortex, hippocampus, and striatum regions. Other tissues express α-Synuclein at very low levels. The physiological role of α-synuclein is not yet well understood. However, the presence of imperfect KTKEGV lipid interacting repeats suggests that it may be involved in synaptic vesicle homeostasis.
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Full-length Recombinant rat α-synuclein (GenBank Accession # NP_062042) was expressed in E. coli and purified from bacterial lysate using proprietary method. Endotoxin was further removed by proprietary technique (<0.1EU/ug protein). The molecular weight of the recombinant α-synuclein protein is 14,515 Da.