Peptides

Endothelin 1, human, HiLyte™ Fluor 488-labeled - 0.25 mg

417.00
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  • Cat.Number : AS-64817-025
  • Availability :
    In stock

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Quantity

This is a fluorescent (HiLyte™ Fluor 488)-labeled Endothelin 1 (ET-1) peptide, Abs/Em=503/528 nm. ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.

Specifications

Chemistry
Sequence one letter code
  • HiLyte™ Fluor 488-CSCSSLMDKECVYFCHLDIIW (Disulfide Bridge: 1-15 and 3-11)
Sequence three letter code
  • Hilyte™ Fluor 488-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide Bridge: 1-15 and 3-11)
Molecular Mass/ Weight
  • 2848.4
Properties
Absorbance (nm)
  • 503
Emission (nm)
  • 528
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Desensitization and internalization of endothelin receptor A: impact of G protein-coupled receptor kinase 2 (GRK2)-mediated phosphorylation.

J Biol Chem . 2013 Sep 24 ; 288(45) 32138 | DOI : 10.1074/jbc.M113.461566.

  • F. Gärtner
  • et al