Neurotensin is a 13 amino acid neuropeptide first isolated from bovine hypothalamus. It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract, where it inducessmooth muscle contraction. In the CNS, neurotensin has a dual function of neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It also shows potent hypothermic and analgesic effects in the brain. Neurotensin has been implicated in the pathophysiology of schizophrenia, Huntington, and Parkinson diseases.
This peptide is a stable neurotensin analog.