[Pyr1]-Apelin-13 - 1 mg
- Cat.Number : AS-60833
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[125I]-(Pyr1)Apelin-13 binds with high affinity and selectivity to human cardiac tissue. Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77). Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue.
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Citations
Increased bone mass in mice lacking the adipokine apelin.
Endocrinol . 2013 Apr 12 ; 154(6) 2069 | DOI : 10.1210/en.2012-2034
- L. Wattanachanya
- et al