Peptides

[Pyr1]-Apelin-13 - 1 mg

77.00
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  • Cat.Number : AS-60833
  • Availability :
    In stock

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[125I]-(Pyr1)Apelin-13 binds with high affinity and selectivity to human cardiac tissue. Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids. Upon signal peptide cleavage, the proprotein of 55 amino acids may generate several active fragments: Apelin-36 (36 aa corresponding to the sequence 42-77), Apelin-17 (17 aa corresponding to the sequence 61-77) and Apelin-13 (13 aa corresponding to the sequence 65-77). Apelin-13 may undergo a pyroglutamylation at its N-terminal glutamine residue.

Specifications

Chemistry
Sequence one letter code
  • Pyr-RPRLSHKGPMPF-OH
Sequence three letter code
  • Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
CAS registry number
  • 217082-60-5
Molecular Formula
  • C69H108N22O16S
Molecular Mass/ Weight
  • 1533.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, mouse, bovine, rat
Codes
Code Nacres
  • NA.26

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Citations

Increased bone mass in mice lacking the adipokine apelin.

Endocrinol . 2013 Apr 12 ; 154(6) 2069 | DOI : 10.1210/en.2012-2034

  • L. Wattanachanya
  • et al