ASO Manufacturing
ScreenToLead™ Oligos
Our ScreenToLead™ Oligos service streamlines your candidate screening process by providing tailored ASOs with rapid turnaround times.
Predefined ASO packages
for drug discovery
Efficient screening is a key step in early drug development, helping identify the most promising antisense oligonucleotide (ASO) candidates. We offer two predefined ASO packages with carefully selected parameters, ensuring oligonucleotides with the right quality standards for efficient high-throughput screening of potential drug candidates.
| Package | Specifications |
|---|---|
| Custom-Modified ASOs Cat# SC-STL-Full |
ScreenToLead™ Oligos - 15–22-mer ASOs with partially to fully modified sequences. |
| Gapmer ASOs Cat# SC-STL-GAP |
ScreenToLead™ Oligos - 15-22-mer Gapmer ASOs with a maximum of 10 modifications. |
Six reasons to choose
ScreenToLead™ Oligos
Tailored ASO synthesis
Custom ASOs from 15 to 22 nucleotides, with a minimum delivery of 10 nmoles per ASO, scalable to larger batches.
Chemistries & modifications
Offering LNA®, 2'O-Me, 2'O-MOE, 2’-Fluoro RNA, and full Phosphorothioate backbones, supporting stability, binding affinity, and efficacy.
High-throughput synthesis
Shasta synthesizers enable the simultaneous synthesis of up to 192 oligonucleotides, accelerating candidate screening.
Purification options
SePOP desalting is provided by default, with HPLC purification available on request for projects requiring higher purity.
Quality
controls
Mass spectrometry and single quantification provide oligos with the appropriate quality for effective screening applications.
Delivery
format
Delivered dried in single tubes, ensuring convenient handling and easy integration into your screening workflows.
Ordering specification
- Minimum Order: 20 oligos per set.
- Format: Desalted, dried in single tubes.
- Optional Purification: HPLC purification available upon request.
- Delivery Time: Average turnaround of 2–3 weeks.
How to get started
Prepare Your Sequences: Compile the ASO sequences you wish to synthesize in the Excel file.
Request a Quote: Send your file to receive a personalized quote.
