Peptides

Protease-Activated Receptor-1, PAR-1 Agonist 1, amide - 5 mg

193.00
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  • Cat.Number : AS-62937
  • Availability :
    In stock

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Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.

Specifications

Chemistry
Sequence one letter code
  • TFLLRN-NH2
Sequence three letter code
  • H-Thr-Phe-Leu-Leu-Arg-Asn-NH2
Molecular Formula
  • C35H59N11O8
Molecular Mass/ Weight
  • 761.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms 1

J Immunol . 2005 Aug 15 ; 175(4) 2598 | DOI : 10.4049/jimmunol.175.4.2598

  • X. Su
  • et al

Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells.

Am J Physiol Lung Cell Mol Physiol. . 2009 Apr 10 ; 296(6) L979 | DOI : 10.1152/ajplung.90412.2008

  • AL. Firth
  • et al

Thrombin- and Factor Xa–induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.

Circ. Res . 2003 Dec 11 ; 94(3) 340 | DOI : 10.1161/01.RES.0000111805.09592.D8

  • BH. Rauch
  • et al

Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1

Int J Cancer. . 2010 Feb 01 ; 126(3) 599 | DOI : 10.1002/ijc.24904

  • W. Wang
  • et al

Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2.

Mol Cancer Res. . 2008 Jun 01 ; 6(6) 1D46 | DOI : 10.1158/1541-7786.MCR-08-0096

  • G. Mize
  • et al

Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells

Am J Respir Cell Mol Biol. . 2013 Nov 01 ; 49(5) 741 | DOI : 10.1165/rcmb.2012-0304OC

  • H. Kouzaki
  • et al