Peptides

Protease-Activated Receptor-1, PAR-1 Agonist 2, amide - 1 mg

66.00
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  • Cat.Number : AS-62936
  • Availability :
    In stock

Quantity

This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.

Specifications

Chemistry
Sequence one letter code
  • TFLLRNPNDK-NH2
Sequence three letter code
  • H-Thr-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-NH2
Molecular Formula
  • C54H89N17O15
Molecular Mass/ Weight
  • 1216.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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Citations

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

Blood . 2012 Nov 13 ; 120(26) 5237 | DOI : 10.1182/blood-2012-08-452169

  • LO. Mosnier
  • et al