Peptides

Protease-Activated Receptor-1, PAR-1 Agonist 3, amide - 1 mg

186.00
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  • Cat.Number : AS-65479
  • Availability :
    In stock

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Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.

Specifications

Chemistry
Sequence one letter code
  • AF(para-Fluoro)R-Cha-Cit-Y-NH2
Sequence three letter code
  • Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
Molecular Mass/ Weight
  • 883
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human
Codes
Code Nacres
  • NA.26

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