Peptides

Thrombin Receptor Activator for Peptide 6 (TRAP-6)

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  • Cat.Number : AS-24190
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This peptide corresponds to aa 42-47 of protease-activated receptor-1 (PAR-1) generated upon thrombin cleavage. This sequence is a PAR agonist, acting as a tethered peptide ligand. Free SFLLRN activates PAR-1 independent of receptor cleavage and has been used to probe PAR-1 function in various cells and tissues. This peptide is also known to be capable of activating PAR-2.

Specifications

Chemistry
Sequence one letter code
  • SFLLRN
Sequence three letter code
  • H-Ser-Phe-Leu-Leu-Arg-Asn-OH
CAS registry number
  • 141136-83-6
Molecular Formula
  • C34H56N10O9
Molecular Mass/ Weight
  • 748.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Bile salt–dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans

J Clinical Invest . 2007 Dec 01 ; 117(12) 3708 | DOI : 10.1172/JCI32655

  • L. Panicot-Dubois
  • et al

P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation

J Thrombosis Haemostasis . 2006 Apr 01 ; 4(4) 882 | DOI : 10.1111/j.1538-7836.2006.01849.x

  • JA. Erhard
  • et al

Ligation of protease-activated receptor 1 enhances αv β6 integrin–dependent TGF-β activation and promotes acute lung injury

J Clin Invest. . 2006 May 18 ; 116(6) 1606 | DOI : 10.1172/JCI27183

  • RG. Jenkins
  • et al

Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling.

Transl Res. . 2010 Jan 01 ; 155(1) 44 | DOI : 10.1016/j.trsl.2009.09.002

  • A. Birukova
  • et al

PAR1 Cleavage and signaling in response to activated protein C and thrombin

J Biol Chem.  . 2005 Jan 21 ; 280(13) 13122 | DOI : 10.1074/jbc.M410381200

  • M. Ludeman
  • et al

Novel role of microtubules in thrombin-induced endothelial barrier dysfunction

FASEB J . 2004 Dec 01 ; 18(15) 1879 | DOI : 10.1096/fj.04-2328com

  • A. Birukova
  • et al

Differential Regulation of human lung epithelial and endothelial barrier function by thrombin

Am J Respir Cell Mol Biol.  . 2004 Jul 29 ; 31(5) 517 | DOI : 10.1165/rcmb.2003-0432OC

  • K. Kawkitinarong
  • et al

Regulated shedding of PAR1 N-terminal exodomain from endothelial cells

J Biol Chem.  . 2004 Feb 24 ; 279(18) 18592 | DOI : 10.1074/jbc.M310836200

  • M. Ludeman
  • et al