BioPharmaceuticals Production
GMP Plasmid DNA Manufacturing
We produce GMP Plasmid DNA for starting material, or API since 2004.
We have developed a platform production process that provides GMP grade plasmid in scales from gram to kilogram that is recognized by numerous big pharma companies for quality and scalability.
Why work with us?
Innovative scalable process
Plasmid manufacturing from 80L to 2200L scale
We manufacture plasmid up to the kg scale with lower quantities of raw materials, volumes of solvents and waste.
We currently manufacturing plasmid DNA for big pharma companies worldwide.
GMP Plasmid DNA to kg-scale
Our 2200L fermenter combined with our purification process allow the production of plasmid DNA to the kilo-scale for commercial uses.
Looking for trusted quality for your GMP Plasmid DNA manufacturing?
Benefit from our decades of GMP plasmid expertise.
Experience
- Plasmid experience from 2.5-16.5 kb
- Numerous antibiotic-free plasmid technologies
- High yielding, high purity proprietary one-chromatography-step purification technology
Quality
- Manufacturing in US FDA inspected facility, inspected 2011, 2013, 2014, 2017
- Drug Master File (DMF) in place with US FDA for easy CMC dossier submission
- Platform GMP plasmid DNA production, scalable for early clinical to commercial
- Non-animal origin materials
Quantity
- Batch sizes up to kg scale manufacturing
- Plasmid concentration from 1-15 mg/ml
- High yielding licensed HyperGro® fermentation technology
- High yielding, high purity proprietary one-chromatography-step purification technology yielding plasmid DNA exceeding FDA quality guidelines

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Oligonucleotides
Wide range of synthesis scales
DNA, RNA, siRNA conjugates
Length : 10 - 40 bases
Modifications :
- Phosphorothioate linkage
- Dye labeling (FAM, HEX ,TET, etc)
- Biotinylation
- Spacer (C3, HEG, etc)
- 2′-O-methyl RNA for preventing ribonucleases
degradation of RNA - peptide conjugates

Peptides
Wide range of synthesis scales
Length : 5-22 amino acids
Frequently-asked modifications :
- Acetylation
- Phosphorylation, methylation
- Biotinylation
- Spacer (Ahx, AEEAc, etc)
- Fatty acids conjugation
- Dye-Labeling (FAM, TAMRA, etc)

miRNA Inhibitors
Chemically modified antisense RNA oligos optimized to specifically target miRNA molecules in cells

miRNA mimics
Custom double-stranded synthetic miRNAs mimicking the action of endogenous miRNAs

Negative siRNA Controls
Validated siRNA sequences presenting no homology with any known eukaryotic gene

Positive siRNA Controls
siRNA sequences directed against a range of endogenous and reporter genes

Custom heavy Isotope Labeled Peptides

Catalog ClearPoint™ Peptides

ELISA Testing

IgY isolation

Affinity purification

Labeling & Conjugation

How to provide my antigen?

Other polyclonal programs

Fermentation

Fermentation in Pichia

GMP Protein Conjugates

GMP Antibody Fragments

Outsourcing clinical phase biologics development.

Analytical Method Lifecycle. A Roadmap for Biopharmaceutical Development



Antigen design

Labeling

Purification

Pre-Immune testing

Fragmentation

Epitope mapping

ELISA

Lab Developed Test Solutions

OEM / Kit Manufacturing

Custom Amplification Reagents

Dried qPCR kits for probe assays

GMP Recombinant proteins
We manufacture GMP recombinant proteins in yeast and bacteria according to FDA and EMA requirements.

VHH antibody fragment

Monoclonal antibodies

Polyclonal antibodies

Camelid antibodies

GMP Recombinant proteins
We manufacture GMP recombinant proteins in yeast and bacteria according to FDA and EMA requirements.

GMP biomanufacturing

Hydrocarbon Stapled Peptides

Disulfide-Bridged Peptides

Cyclic Peptides

Monoclonal antibody

NeoAntigens

QC Controls & Standards for biopharmaceuticals & API's

Ex-vivo cell therapy

Diagnostic testing

Pre-clinical animal testing

Skin cosmetics

Biomaterial Peptide Coatings

BioPharmaceutical manufacturing materials & precursors

Custom Peptides Synthesis
From simple to complex sequences

FRET peptides
We offer a full-range of dye-quencher FRET pairs

TR-FRET peptides
We produce custom peptides labeled with lanthanide metal as donor

Labeling Reagents
Get access to a large collection of molecules

Catalog peptides

Fluorescent Dyes

Fret peptides

GMP peptide manufacturing

Murine hybridoma development

Monoclonals in vitro production

qPCR products
We provide qPCR Kits, Reagents, plates…

Access™ Dyes & Quenchers
Unmatched detection performance
and IP-friendly terms and conditions

How to provide my antigen?

Dyes & quenchers

Biotin & avidins

FRET & TR-FRET

Western blotting, gels & substrates (TMB, HRP substrate)

Quantitative PCR kits
Discover our range of kits for Realtime qPCR

Quantitative Reverse transcription PCR kits
Discover our range of kits for Realtime RT-qPCR

qPCR plastics
We dispose of a large range of plastics adapted to all platforms

Specialized programs
Discover our offer concerning llama, Chicken, or anti PTM programs.

Additional services
From purifications to epitopes mapping, discover all our antibodies additional services.

Custom antibodies
Discover our offer including monoclonal and polyclonal production by classical or fast immunization programs.

Catalog recombinant proteins
Our catalogue recombinant proteins cover the most common proteins mainly related to neurosciences and cancer research.

Fluorescent Dye Labeled Streptavidin
We offer labeled streptavidin with various fluorescent molecules for FRET and TR-FRET applications.

Protein labeling Kits
Our AnaTag™ labeling kits provide a convenient way to label your proteins for TR-FRET.

Large Scale Oligo
We produce custom oligonucleotides from micrograms to a few dozen hundred grams.

Oligo Aptamers
We provide high-value aptamer-related services which include the selection and production of custom optimized RNA and DNA aptamers.

GeneReleaser
Facilitates the release of DNA from whole blood, tissues, bacteria, yeasts and plants.

Kaneka endonuclease
Kaneka endonuclease cleaves with high efficiency all kinds of nucleic acid strands into small fragments.

Design Assistance
Our oligonucleotide experts design your qPCR probes, siRNA and miRNA

Custom Oligo
We produce a large variety of oligonucleotides from PCR primers to complex sequences

IVD Oligonucleotides

Lab developped tests

Antibodies against PTM

Quantified peptides

ASR oligonucleotides

Extraction & purification kits

Quality
From Research to GMP

Quality assurance
QA for GMP products

Need a tailor made qPCR kit ?
Design and manufacturing of your own custom-formulated amplification reagents.

Dry qPCR kits
Besides the liquid format, Takyon™ MasterMixes for Probe Assays are also available in a lyophilised format.

Polyclonal programs

Animal welfare

DNA template

RNA template

RT-qPCR Reagents
Detect the virus in samples from infected patients

Custom Oligonucleotide Synthesis
Configure your primers and probes for nucleic acid detection

Gene Synthesis
Get Positive controls and Covid related custom genes

Synthesis Reagents
Critical raw materials for COVID research and diagnostics

Custom Antibodies
Detect the virus in samples from potentially infected patients

Peptide library
Screen your test compounds on peptides from Spike protein sequence of SARS-CoV-2

Protease Substrates
Develop inhibitors of viral infection

Assay kits
Screen for inhibitors and find potential therapeutic targets

Genomics
We are actively producing oligonucleotides, genes and RT-qPCR reagents.

Proteomics
We offer catalog peptides, fluorescent dyes, and assay kits. We develop customized solutions.

Documentation

FAQs

Protein Electrophoresis

HRP Substrate for Western Blotting

Speedy Custom Antibodies

Plates & Tubes

DNA Purification and extraction kits

PCR Mixes

Polymerases

dNTPS (Li Salts)

SARS-CoV-2 genome
Coronavirus genes, phylogeny, life cycle, and evolution

SARS-CoV-2 proteins
Structural, non-structural and accessory proteins roles

SARS-CoV-2 serological tests
Indentify SARS-CoV-2 antibodies to study COVID-19 immunity

COVID-19 diagnostic tests
Detect 2019-nCoV RNA sequence in biological sample

SARS-CoV-2 vaccines
New generation of treatments and vaccines against COVID-19

Electrophoresis Device

Agarose

DNA Molecular weight Markers

Electroporation cuvettes

siRNA Controls

Housekeeping qPCR controls

qPCR internal positive controls

qPCR Extraction & inhibition controls

Adhesion Recombinant proteins
A collection of human recombinant MMPs and catalytic domains

MMP Peptides
A unique collection of MMP substrates

VHH antibody fragment

qPCR products

Browse Probes Catalog

Check your Thermocycler &
Fluorescent Dyes compatibility

Find the best Dye and Quencher pair

Find the best Dye and Quencher pair

Discover our Oligonucleotide documentation

Batch order
Multiple Probes

qPCR Probes
Dual labeled probes for any qPCR channel.

qPCR Controls
Positive Controls for TaqMan® Assays.

qPCR Plastics
Optimal heat transfer and signal uniformity.

Lab Developed Test Solutions
Your LDTs delivered in a ready-to-use format instead of individual components.

In-house assay solutions
A flexible and custom service for the preparation of your in-house assay in a ready-to-use format

Solution for kit manufacturers

Large-scale antibody production
Monoclonal and polyclonal for the industry

Polyclonal antibody programs
Classical or fast immunization programs

Custom hybridoma
From antigen design to hydridoma development

Boost my hybridoma’s
Proprietary protocol to boost the clone productivity

GMP Plasmid DNA

GMP Recombinant Proteins

Monoclonal Antibody Services

Primers & Probes

Plastics

Controls

Services for Diagnostics

qPCR Probes

qPCR Primers

IP-friendly Dyes

Custom Reagents

Need a tailor made qPCR kit ?
Design and manufacturing of your own custom-formulated amplification reagents.

Large-scale Oligonucleotides
Get bulk quantities of purified custom oligonucleotides

One-Step Kit Converter

Plastics

Blue Additive

Oligonucleotides

Peptide Oligo conjugates

GMP Peptide Manufacturing
We specialize in GMP peptide manufacturing, ensuring high-quality peptides for therapeutic applications.

GMP mRNA synthesis
We provide mRNA enzymatic manufacturing, from plasmid production to GMP-grade mRNA delivery.

GLP & Animal studies
We provide expert support for conducting GLP-compliant in-vivo and in-vitro pre-clinical studies.

GMP BioManufacturing
We produce clinical trial and commercial material.

Therapeutic
Oligos
End-to-end solutions for innovative therapies.

Animal
Welfare
We follow 3Rs guidelines for continuous improvement.

Industrial scale antibodies
Custom monoclonal and polyclonal antibodies in large volume.

Therapeutic Oligonucleotides
Comprehensive end-to-end solutions

mRNA manufacturing
GMP production from 0.5 to 50g scale

Biopharma CDMO Services
GMP Plasmid DNA and recombinant proteins

Animal and analytical GLP Services
Tailored study designs, and IND filing support

GMP IVD Oligonucleotides
We produce oligos for IVD in Classified cleanrooms.

Lab Developed Test
Tailored and adaptable service for preparing your Lab Developed Tests (LDTs) in a convenient, ready-to-use format.

Takyon™ qPCR Kits for Probe Assays
With the Takyon® kits get access to a new level of speed in your qPCR applications.

Custom Kit Manufacturing
Benefits from our expertise, technologies and equipment to accelerate diagnostic market entry of your nucleic-acid based assays.

GLP & Animal studies
We provide expert support for conducting GLP-compliant in vivo and in vitro pre-clinical studies.

GMP Oligo manufacturing
End-to-end solutions for the development and manufacturing of high-quality oligonucleotides.

GMP Plasmids
For starting material or human API

GMP Proteins
Manufacturing experience in E.coli and P.pastoris

GMP Oligos
Small to large manufacturing scales

GMP Peptides
Continuum from discovery to clinical use

PNA FISH Probes
Catalog of high-quality PNA FISH probes for precise and rapid nucleic acid detection.

Custom Oligos
Custom synthesis from routine research primers to complex nucleotide sequences.

Diagnostics
Expertise in manufacturing amplification reagents for molecular diagnostics assays.

Therapeutic Oligos
End-to-end solutions for the development and manufacturing of high-quality oligos.

Diagnostic Oligos
We produce oligos for IVD in Classified cleanrooms.

qPCR kits
We produce and deliver reagents for qPCR assays from individual components to MasterMixes.

Custom kits
We produce, package and release your nucleic acid-based assays.

Lab developed Tests
We offer a highly flexible and custom service for the preparation and the delivery of your Lab Developed Tests (LDTs) in a ready-to-use format.

ASO manufacturing
With over 40 years of experience in oligonucleotide production, we offer tailored solutions for manufacturing custom ASOs.

GMP oligo manufacturing
End-to-end solutions for the development and manufacturing of high-quality oligonucleotides.

RUO Grade VHH antibodies
We generate custom VHH for research use from llama immunization.

GMP antibody fragments
We produce GMP Ab fragments such as scFv, Fab, diabody, and bispecific tandem scFv.

GMP recombinant protein
We manufacture GMP recombinant proteins in yeast and bacteria according to FDA and EMA requirements.

GMP Protein Conjugates
We offer protein conjugation such as peptide-protein conjugates and PEGylated proteins.

GMP Proteins
Manufacturing experience in E.coli and P.pastoris

GMP mRNA synthesis
We provide mRNA enzymatic manufacturing, from plasmid production to GMP-grade mRNA delivery.

GMP Oligos
Small to large manufacturing scales.

GMP Peptides
Continuum from discovery to clinical use.